Hepatic enzymes of nonhuman primates

a bibliography / Benella Caminiti. by Benella Caminiti

Publisher: University of Washington, Regional Primate Research Center, Primate Information Center in Seattle, Wash

Written in English
Published: Pages: 24 Downloads: 638
Share This

Subjects:

  • Primates -- Bibliography,
  • Liver -- enzymology -- Bibliography

Edition Notes

GenreBibliography.
ContributionsUniversity of Washington. Primate Information Center.
The Physical Object
Pagination24 p. ;
Number of Pages24
ID Numbers
Open LibraryOL14754520M
OCLC/WorldCa7480846

OCLC Number: Description: xxiii, pages illustrations 25 cm: Contents: Immunological studies on the human response to chimpanzee tissue antigens / Richard S. Metzgar and H.F. Seigler --The distribution of human HL-A antigens in chimpanzees and gorillas / Martin E. Dorf and Richard S. Metzgar --Nonhuman primate preclinical antilymphocyte serum testing / J.J. Smith, C. Darrow, K.W Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primates. Mol Ther ; – CAS Trans-fatty acid consumption has been reported as a risk factor for metabolic disorders and targeted organ damages. Nonetheless, little is known about the roles and mechanisms of trans-fatty acids in obesity, insulin resistance (IR) and hepatic steatosis. Adult C57BL/6 male mice were fed with four different diets for 20 weeks: normal diet (ND), high fat diet (HFD), low trans-fatty acids diet human primates to man (3). Such primate-associated human cases may, however, result from several mechanisms. They may represent an original transmission from man to nonhuman primates. Multiplication and excretion of the agent by the primate may ?doi=&rep=rep1&type=pdf.

  IN THIS JOURNAL. Journal Home. Browse Journal. Current Issue; OnlineFirst; Accepted Manuscripts; All Issues   Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of McCurdy, CE, Bishop, JM, Williams, SM et al. () Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest , – Since , the United States has been dealing with an ongoing, nationwide outbreak of hepatitis A infections. According to the Centers for Disease Control and Prevention, between and

  Hepatic Steatosis and Fibrosis in Obese, Dysmetabolic and Diabetic Nonhuman Primates Quantified by Noninvasive Echography Yongqiang Liu 1, Haihua Gu2, Hui Wang, Bingdi Wang, Xiaoli Wang1, George Aoyagi2, Yong-Fu Xiao1, Keefe Chng2, Xing Gao3, Jinhu Wang4, Eiketsu Sho5, Yao-Ping Lin6 and Yi Xin (Jim) Wang1,2* 1Crown Bioscience, Inc. Taicang, China 2Crown Bioscience, Inc. Secondary hepatic amyloidosis in nonhuman primates carries a grave prognosis once animals become clinically ill. The purpose of this study was to establish serologic parameters that potentially could be used to identify rhesus macaques undergoing subclinical development of secondary hepatic amyloidosis. A retrospective analysis was completed by using serum biochemical profiles from 26 Baboon hepatic and placental microsomes were investigated to validate the nonhuman primate as an animal model for drug use during pregnancy. Data presented here indicate that human and baboon hepatic microsomes formed several mono-, di-, and tri-hydroxylated derivatives of ://

Hepatic enzymes of nonhuman primates by Benella Caminiti Download PDF EPUB FB2

SUMMARY The activity of hepatic microsomal drug-metaboUing enzymes in the baboon (P. anubis) and rhesus monkey (M. mulatta) was similar, and generally of similar magnitude to that in rats. Following chronic oral administration of DDT to each species, enzyme activity and cytochrome P concentrations were generally increased by up to ://   In marmosets, the oxidation activities of hepatic microsomes and intestinal microsomes were roughly comparable for midazolam and terfenadine.

Overall, multiple forms of marmoset P enzymes in livers and intestines had generally similar substrate recognition functionalities to those of human and/or cynomolgus monkey P Background: Non-human primates are valuable animal models in drug discovery and biomedical research.

Human CYP2D6 accounts for % of total hepatic CYP content in the liver, but is involved Cell Metabolism Article DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates David G. McLaren,2,6,8,* Seongah Han,1,6,* Beth Ann Murphy,2 Larissa Wilsie,1 Steven J.

Stout,2 Haihong Zhou,1 Thomas P. Roddy,1 Judith N. Gorski,2 Daniel E. Metzger,2 Myung K. Shin,3 Dermot F. Reilly,3 Heather H. Zhou,1 Marija Tadin-Strapps,3 Steven R. Bartz,4 Anne-Marie (18) There remains little research in this field, although a small number of groups have explored liver xenotransplantation in nonhuman primate models [12–17] (Tables 1, 2).

Porter [6] and Wight [19] have reviewed the histopathological features of hepatic xenograft :// Abstract. Close similarities exist in the hyperbilirubinemic responses in inherited and acquired hepatic disorders between human and nonhuman primates (1); only little differences exist in the chemical structure of fetal and adult bile pigments and hepatic bilirubin conjugating enzymes (2).

The disease in nonhuman primates is much less severe than the disease in humans, and is often subclinical. Some species of nonhuman primates develop malaise, vomiting, jaundice, and increased serum concentrations of hepatic enzymes.

The disease in humans varies from a mild illness lasting weeks to a severely debilitating illness lasting   Maternal obesity is thought to increase the offspring’s risk of juvenile obesity and metabolic diseases; however, the mechanism(s) whereby excess maternal nutrition affects fetal development remain poorly understood.

Here, we investigated in nonhuman primates the effect of chronic high-fat diet (HFD) on the development of fetal metabolic :// Their controlled-release mitochondrial protonophore (CRMP) improved insulin resistance, dyslipidemia, and hepatic steatosis in nonhuman Hepatic enzymes of nonhuman primates book treated over the course of 6 weeks, without increases in oxidative stress, liver enzymes, or adverse :// The plasma concentration-time profile of doxorubicin in nonhuman primates is shown in Fig.

Fig 1. The initial rapid decline in the plasma doxorubicin concentration after completion of the 1-h infusion, followed by the prolonged elimination phase, is similar to the profile observed in ://   model and demonstrated almost complete penetration of hepatic tissues following intravenous injection in nonhuman primates (NHPs).

Yet liver toxicity was observed in a dose-dependent man-ner, which we hypothesized was due to the strong transcriptional activity of each of the Pol III promoters and led to an overabun-dance of ://(   Similarly the dog has also been reported to be less sensitive to the barbiturate than are rodents (McKillop, ; Muller et al., ) and in general both the nonhuman primate and the dog have been reported to be less responsive to the induction of enzymes by so-called classic inducers of rodent hepatic ://   Nutrient Requirements of Nonhuman Primates, Second Revised Edition () Nutrient Requirements of Swine, Tenth Revised Edition () Pesticide Resistance: Strategies and Tactics for Management () Pesticides and Groundwater Quality: Issues and Problems in Four States () Pesticides in the Diets of Infants and Children ()   Here, we investigated in nonhuman primates the effect of chronic high-fat diet (HFD) on the development of fetal metabolic systems.

We found that fetal offspring from both lean and obese mothers chronically consum-ing a HFD had a 3-fold increase in liver triglycerides (TGs).

In addition, fetal offspring from HFD-fed   For example, in humans and nonhuman primates (NHPs), the development of WAT occurs during the third trimester (36, 37).

It is well accepted that WAT is critical for storage of excess lipids and that a lack of WAT results in whole-body insulin resistance and susceptibility to fatty liver in adult humans ( This chapter discusses nonhuman primates used in virus research.

The use of nonhuman primates in biomedical research is not a recent development. The examination of the literature concerned with experimental medicine provides evidence for the use of one or another species of monkey or ape from early recorded ://   Although numerous studies have demonstrated the feasibility of isolating primary hepatocytes or hepatic progenitor cells from human liver or other nonhuman primates Effect of age on the development of cor pulmonale in nonhuman primates following pyrrolizidine alkaloid intoxication.

Effect of polychlorinated biphenyls on hepatic microsomal enzymes in the rat. Effect of starvation on NADPH-dependent enzymes in liver microsomes of male and female :// 2 days ago  A closer relationship between higher primates and humans in growth patterns suggests that nonhuman primates would be more realistic experimental models.

Nonhuman-primate models of protein-calorie malnutrition (PCM) could provide a means to study biochemical and physiologic responses to a primary deficiency of either protein or energy and could The origins of nonalcoholic fatty liver disease (NAFLD) may lie in early intrauterine exposures.

Here we examined the maternal response to chronic maternal high-fat (HF) diet and the impact of postweaning healthy diet on mechanisms for NAFLD development in juvenile nonhuman primate (NHP) offspring at 1 year of age.

Pregnant females on HF diet were segregated as insulin resistant (IR; HF+IR) or   The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science.

By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, Fluconazole was not continued after the doxorubicin dose, because it has a long t 1/2 (25 h in nonhuman primates, ± 4 h in humans), which results in prolonged drug exposure (2, 3).

Complete blood counts and chemistries were performed on the animals twice weekly for In marmosets, the oxidation activities of hepatic microsomes and intestinal microsomes were roughly comparable for midazolam and terfenadine.

Overall, multiple forms of marmoset P enzymes in livers and intestines had generally similar substrate recognition functionalities to those of human and/or cynomolgus monkey P   Research over the past 30 years has elucidated the roles of polymorphic human liver cytochrome P (P) enzymes associated with toxicological and/or pharmacological actions.

Thalidomide exerts its various pharmacological and toxic actions in primates through multiple mechanisms, including nonspecific modification of many protein networks after bioactivation by autoinduced human P :// Thus, these favorable results in nonhuman primates provide important insight to the fate of fCNT in vivo and pave the way to further engineering design considerations for sophisticated nanomedicines to aid late stage development and clinical use in man.}, doi = {/}, journal = {PLoS ONE}, number = 8, volume = 12, place The biological response of infant nonhuman primates to a polychlorinated biphenyl.

Effect of polychlorinated biphenyls on hepatic microsomal enzymes in the rat. Toxicol Appl Pharmacol. Sep; 23 (1)– Grant DL, Phillips WE, Villeneuve DC. Metabolism of a polychlorinated biphenyl (Aroclor ) mixture in the rat.

Bull Environ Cardiac, hepatic and renal complications in spontaneously developed diabetic nonhuman primates International Conference on Diabetes and its Complications MayOsaka, Japan.

Yong Fu Xiao and Yi Xin Jim Wang. Crown Bioscience Inc., USA. Nonhuman primates have long been recognized as good mod- enzymes are candidate sites for regulation. We have shown that when atherogenic diets are fed to primates, the extent of hepatic cholesteryl ester secretion in response to dietary fatty acids is highly correlated to the extent of CAA (10).

We demonstrate in nonhuman primates that this novel method of vector delivery results in an exceedingly high and unprecedented level of hepatic transduction with low vector doses resulting in Meta‐analysis of hepatic cytochrome P ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling -based pharmacokinetic model to explore the potential disparity in nicotine disposition between adult and adolescent nonhuman primates, Abby C.

Collier, Stephan Schmidt, Neil. Here, we investigated in nonhuman primates the effect of chronic high-fat diet (HFD) on the development of fetal metabolic systems.

We found that fetal offspring from both lean and obese mothers chronically consuming a HFD had a 3-fold increase in liver triglycerides (TGs).Symposium on the Use of Subhuman Primates in Drug Evaluation ( San Antonio, Tex.).

Use of nonhuman primates in drug evaluation. Austin, University of Texas Press [] (OCoLC) Online version: Symposium on the Use of Subhuman Primates in Drug Evaluation ( San Antonio, Tex.). Use of nonhuman primates in drug ://  (AAVhu68) using this approach, three juvenile nonhuman primates (NHPs; aged 14 months) and three piglets (aged 7–30 days) were treated with an i.v.

injection of an AAVhu68 vector carrying a human SMN transgene at a dose similar to that employed in the